Molecular Profiling in the Diagnosis of Gliomas

In this presentation, pathologist Maria Martinez­-Lage, MD, offers a profile of the four subtypes of glioblastoma as identified by gene expression analysis and molecular signatures, as well as  their respective genomic alterations, prognoses and signaling pathways, and discusses the approach of the new WHO classification of glioblastoma and current efforts at the Penn Center for Personalized Diagnosis to expand the panel of known gene mutations for the disease.