Grand Rounds: Individualizing Diagnosis and Therapy for IBS

Arthur Beyder, M.D., Ph.D., and Gianrico Farrugia, M.D., discuss the morbidity, pathophysiology and genetics of irritable bowel syndrome (IBS), a complex genetic disease. In some cases, IBS is an ion channelopathy. Drs. Beyder and Farrugia discuss the involvement of SCN5A and NaV1.5 mutations in patients with IBS.

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