Autophagy and Neurons — Targeting Protein Quality Control for Modifying Proteostasis and Discovering Therapeutic Targets for Neurodegenerative Diseases

Johns Hopkins neurologist Jason Chua recaps a recent presentation about the discovery of a novel mechanism of modulating autophagy, a conserved pathway of protein quality control. He discusses how modulating autophagy can be done specifically in neurons that enhance the breakdown of protein substrates, including those implicated in neurodegeneration. This discovery has broad therapeutic implications for neurodegenerative diseases hallmarked by protein aggregation and loss of protein quality control.

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Jason Chua, M.D., Ph.D..

Jason Chua, M.D., Ph.D.

Assistant Professor of Neurology

Dr. Chua is an assistant professor in the Department of Neurology and Division of Movement Disorders at  Johns Hopkins. He received his training at the University of Michigan, where he obtained medical and graduate degrees, then completed ...

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