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Excessive Negative Regulation of Type I Interferon Disrupts Viral Control in Individuals with Down Syndrome

In April 2020, as the COVID-19 pandemic spread through New York City, Louise Malle, an MD/PhD candidate at the Icahn School of Medicine at Mount Sinai, turned her focus to the disturbing statistics coming out on disease severity. She thought the data might inform her research to better understand immunity in people with Down syndrome.

Ms. Malle, who works in the lab of Dusan Bogunovic, PhD, surveyed thousands of patients diagnosed with COVID-19, and essentially found that individuals with the syndrome have about 10 times the likelihood of having extremely severe disease.

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Dusan Bogunovic, PhD.

Dusan Bogunovic, PhD

Associate Professor, Microbiology, and Pediatrics
Director, Center for Inborn Errors of Immunity
The Mindich Child Health and Development Institute
Icahn School of Medicine at Mount Sinai

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