Temple Lung Center | Enrolling Clinical Trials

The Temple Lung Center conducts one of the most comprehensive lung disease clinical trials programs in the country. Our advancements in basic, translational and clinical research are changing lung disease treatment. By pioneering effective therapies, we bring hope to patients with serious and debilitating lung diseases. 
 

Review Our Open Clinical Trials

 


Alpha1-antitrypsin Deficiency

Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency (ATALANTa)
NCT03679598

 


Asthma

ALA-ACRC "Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma" (MATCH) Trial
 
A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Patients With Asthma
NCT04203797
 
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult
Patients With Uncontrolled Moderate to Severe Asthma
NCT05097287

 


Bronchiolitis Obliterans Syndrome (BOS)

 A Clinical Trial to Demonstrate the Effectiveness and Safety of Liposomal Cyclosporine A Inhalation Solution in the Treatment of Bronchiolitis Obliterans Syndrome in Patients Post Single Lung Transplant (BOSTON-1)
 
A Clinical Trial to Demonstrate the Effectiveness and Safety of Liposomal Cyclosporine A Inhalation Solution in the Treatment of Bronchiolitis Obliterans Syndrome in Patients Post Double Lung Transplant (BOSTON-2)
NCT03656926

 

 
COPD

A Multi-center, Randomized, Double-blind, Parallel-group, Placebo-controlled Study of Mepolizumab 100mg SC as add-on Treatment in Participants With COPD Experiencing Frequent Exacerbations and Characterized by Eosinophil Levels (MATINEE)
 
Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)
NCT04069312
 
Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations (RESOLUTE)
NCT04053634
 
Evaluation of the Safety and Efficacy of TLD in Patients With COPD (AIRFLOW-3)
NCT03639051
 
Predicting Sleep, Smoking, and Lung Health Disparities in African American Adults
NCT03534076
 
A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis (Spray-CB)
NCT03893370
 
Clinical Study of the RheOx Bronchial Rheoplasty System in Treating the Symptoms of Chronic Bronchitis (RheSolve)
NCT04677465
 
A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis (FRONTIER-4)
NCT04631016
 
myAirvo 3 (High Flow Nasal Therapy? HFNT) for COPD Patients in the Home
NCT05204888
 
Functional Lung Imaging in Patients with Respiratory Compromise Undergoing Endobronchial Valve Placement
NCT05204875
 
Efficacy and Safety of Tozorakimab (MEDI3506) in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations. (TITANIA)
NCT05158387
 
A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
NCT05037929

 


Interstitial Lung Disease (ILD)

Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry (IPF/ILDPRO)
NCT01915511
 
Autoantibody Reduction for Acute Exacerbations of Idiopathic Pulmonary Fibrosis (STRIVE-IPF)
NCT03286556
 
GKT137831 in IPF Patients With Idiopathic Pulmonary Fibrosis (GKT137831)
NCT03865927
 
Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial (PRECISIONS)
NCT04300920
 
Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis (TETON)
NCT04708782
 
A Randomized, Double Blind, Placebo-controlled, study to investigate the safety, pharmacokinetics and pharmacodynamics of CSL312 in Subjects with Idiopathic Pulmonary Fibrosis
NCT05130970

 


Inpatient

A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning from Mechanical Ventilation in ICU Patients (RESCUE 3)
 
Tolerance and Acute Effects of a New HFNT Nasal Cannula
NCT05182294

Trial of Therapeutic Hypothermia in Patients With ARDS (CHILL)
NCT04545424

 


Mycobacterium Avium Complex Disease

Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease (MAC2v3)

Clofazimine in the Treatment of Pulmonary Mycobacterium Avium Complex (MAC)
NCT02968212

 


Pulmonary Hypertension

A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
NCT03496623

A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension (REBUILD)
NCT03267108

A Study of Rodatristat Ethyl in Patients With Pulmonary Arterial Hypertension (ELEVATE 2)
NCT04712669

 


Lung Cancer

DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers
NCT04165564

 


Other

A Study to Evaluate the Efficacy and Safety of Dupilumab in Participants With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED)
NCT04442269
 
American Lung Association (ALA) Lung Health Cohort
NCT04543461
 
SPIROMICS Study of Early COPD Progression (SOURCE) (SOURCE)
NCT05033990
 
A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE (ASTER)

 

 

For more information about clinical research trials at the Temple Lung Center,
email breathe@temple.edu or call 215-707-1359.