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Temple Lung Center | Enrolling Clinical Trials

The Temple Lung Center conducts one of the most comprehensive lung disease clinical trials programs in the country. Our advancements in basic, translational and clinical research are changing lung disease treatment. By pioneering effective therapies, we bring hope to patients with serious and debilitating lung diseases. 
 

Review Our Open Clinical Trials

 


Asthma

ALA-ACRC "Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma" (MATCH) Trial
 
A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype (NIMBLE)
NCT04718389
 
Effectiveness and Safety Study of Tezepelumab in Adults & Adolescent Participants With Severe Asthma in the United States (PASSAGE)
NCT05329194

 


Bronchiolitis Obliterans Syndrome (BOS)

A Phase III, Extension Clinical Trial to Demonstrate Efficacy and Safety of Liposomal Cyclosprine A Via the PARI Investigational eFlow® Device and SoC in Treating Bronchiolitis Obliterans in Patients Post Single or Double Lung Transplant (BOSTON-3)
 

 


Bronchiectasis

Clinical Effectiveness Of High Frequency Chest Wall Oscillation (HFCWO) In A Bronchiectasis Population (HFCWO)
 

 


Chronic Bronchitis

A Feasibility Study: A Safety Evaluation of RheOx on Patients With Chronic Bronchitis in the United States
 

 

 
COPD

A Multi-center, Randomized, Double-blind, Parallel-group, Placebo-controlled Study of Mepolizumab 100mg SC as add-on Treatment in Participants With COPD Experiencing Frequent Exacerbations and Characterized by Eosinophil Levels (MATINEE)
 
Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)
NCT04069312
 
Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations (RESOLUTE)
NCT04053634
 
Evaluation of the Safety and Efficacy of TLD in Patients With COPD (AIRFLOW-3)
NCT03639051
 
Predicting Sleep, Smoking, and Lung Health Disparities in African American Adults
NCT03534076
 
A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis (Spray-CB)
NCT03893370
 
Clinical Study of the RheOx Bronchial Rheoplasty System in Treating the Symptoms of Chronic Bronchitis (RheSolve)
NCT04677465
 
A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis (FRONTIER-4)
NCT04631016
 
A Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Phase 2a Study to Explore the Efficacy and Safety of Tezepelumab in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) (COURSE)
NCT04039113
 
Immunological Basis for Benralizumab Activity in Chronic Obstructive Pulmonary Disease (COPD)
NCT05273359
 
Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease
NCT05119556
 
Immunological Basis for Mepolizumab Activity in COPD
NCT05320939
 
STRIVE Post-Market Registry Study
NCT04302272
 
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
NCT05204888
 
Functional Lung Imaging in Patients with Respiratory Compromise Undergoing Endobronchial Valve Placement
NCT05204875
 
Efficacy and Safety of Tozorakimab (MEDI3506) in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations. (TITANIA)
NCT05158387
 
A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
NCT05037929

 


Interstitial Lung Disease (ILD)

A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)
NCT05321069
 
A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)
NCT05321082
 
Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry (IPF/ILDPRO)
NCT01915511
 
Autoantibody Reduction for Acute Exacerbations of Idiopathic Pulmonary Fibrosis (STRIVE-IPF)
NCT03286556
 
GKT137831 in IPF Patients With Idiopathic Pulmonary Fibrosis (GKT137831)
NCT03865927
 
Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial (PRECISIONS)
NCT04300920
 
Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis (TETON)
NCT04708782
 
A Randomized, Double Blind, Placebo-controlled, study to investigate the safety, pharmacokinetics and pharmacodynamics of CSL312 in Subjects with Idiopathic Pulmonary Fibrosis
NCT05130970
 
A Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of HZN-825 in Subjects With Idiopathic Pulmonary Fibrosis
NCT05032066
 

 

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Inpatient

Trial of Therapeutic Hypothermia in Patients With ARDS (CHILL)

 


Lung Cancer

DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers

 


Mycobacterium Avium Complex Disease

Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease (MAC2v3)

Clofazimine in the Treatment of Pulmonary Mycobacterium Avium Complex (MAC)
NCT02968212

 


Pulmonary Embolism

The PEERLESS Study (PEERLESS)

A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE (MAGNOLIA)
NCT05171075

 

 

Pulmonary Hypertension

A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension (REBUILD)

A Study of Rodatristat Ethyl in Patients With Pulmonary Arterial Hypertension (ELEVATE 2)
NCT04712669

 

Sarcoidosis

A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis (Pulse-PHPF-002)

A Study to Assess the Efficacy and Safety of Namilumab in Participants With Chronic Pulmonary Sarcoidosis (RESOLVE-Lung)
NCT05314517

 


Other

A Study to Evaluate the Efficacy and Safety of Dupilumab in Participants With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED)
NCT04442269
 
American Lung Association (ALA) Lung Health Cohort
NCT04543461
 
SPIROMICS Study of Early COPD Progression (SOURCE) (SOURCE)
NCT05033990
 
A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE (ASTER)

 

For more information about clinical research trials at the Temple Lung Center,
email breathe@tuhs.temple.edu or call 215-707-1359.

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